TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer.

ABSTRACT: The cancer stroma, including cancer-associated fibroblasts (CAFs), is known to contribute to cancer cell progression and metastasis, suggesting that functional proteins expressed specifically in CAFs might be candidate molecular targets for cancer treatment. The purpose of the present study was to explore the possibility of using TEM1 (tumor endothelial marker 1), which is known to be expressed in several types of mesenchymal cells, as a molecular target by examining the impact of TEM1 expression on clinicopathological factors in gastric cancer patients. A total of 945 consecutive patients with gastric cancer who underwent surgery at the National Cancer Center Hospital East between January 2003 and July 2007 were examined using a tissue microarray approach. TEM1 expression in CAFs or vesse

SUBMITTER: Fujii S 

PROVIDER: S-EPMC4673993 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature