Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation.

ABSTRACT: The lack of capability to quantify oxygen metabolism noninvasively impedes both fundamental investigation and clinical diagnosis of a wide spectrum of diseases including all the major blinding diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Using visible light optical coherence tomography (vis-OCT), we demonstrated accurate and robust measurement of retinal oxygen metabolic rate (rMRO₂) noninvasively in rat eyes. We continuously monitored the regulatory response of oxygen consumption to a progressive hypoxic challenge. We found that both oxygen delivery, and rMRO₂ increased from the highly regulated retinal circulation (RC) under hypoxia, by 0.28 ± 0.08 μL min^-1 (p < 0.001), and 0.20 ± 0.04 μL min^-1 (

SUBMITTER: Yi J 

PROVIDER: S-EPMC4674267 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature