Eosinophil extracellular trap cell death-derived DNA traps: Their presence in secretions and functional attributes.

ABSTRACT:

Background

Activated human eosinophils, as well as neutrophils, can release extracellular chromatin to form DNA traps through cytolytic extracellular trap cell death (ETosis). Although formations of neutrophil DNA traps are recognized in patients with various inflammatory conditions, neither the presence of ETosis-derived eosinophil DNA traps in human allergic diseases nor the characteristics of these DNA traps have been studied.

Objective

We investigated the presence of ETosis-derived DNA traps in eosinophil-rich sinus and ear secretions and the functional attributes of ETosis DNA traps.

Methods

Eosinophil-rich secretions obtained from patients with eosinophilic chronic rhinosinusitis and eosinophilic otitis media were studied microscopically. In vitro studies of ETo

SUBMITTER: Ueki S 

PROVIDER: S-EPMC4674385 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature