Exploring Female Mice Interstrain Differences Relevant for Models of Depression.

ABSTRACT: Depression is an extremely heterogeneous disorder. Diverse molecular mechanisms have been suggested to underlie its etiology. To understand the molecular mechanisms responsible for this complex disorder, researchers have been using animal models extensively, namely mice from various genetic backgrounds and harboring distinct genetic modifications. The use of numerous mouse models has contributed to enrich our knowledge on depression. However, accumulating data also revealed that the intrinsic characteristics of each mouse strain might influence the experimental outcomes, which may justify some conflicting evidence reported in the literature. To further understand the impact of the genetic background, we performed a multimodal comparative study encompassing the most relevant parameters comm

SUBMITTER: de Sa-Calcada D 

PROVIDER: S-EPMC4674561 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature