Associations between Gut Microbial Colonization in Early Life and Respiratory Outcomes in Cystic Fibrosis.

ABSTRACT:

Objective

To examine patterns of microbial colonization of the respiratory and intestinal tracts in early life in infants with cystic fibrosis (CF) and their associations with breastfeeding and clinical outcomes.

Study design

A comprehensive, prospective longitudinal analysis of the upper respiratory and intestinal microbiota in a cohort of infants and young children with CF followed from birth was performed. Genus-level microbial community composition was characterized using 16S-targeted pyrosequencing, and relationships with exposures and outcomes were assessed using linear mixed-effects models, time-to-event analysis, and principal components analysis.

Results

Sequencing of 120 samples from 13 subjects collected from birth to 34 months revealed relationships betwee

SUBMITTER: Hoen AG 

PROVIDER: S-EPMC4674690 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature