EC: an efficient error correction algorithm for short reads.

ABSTRACT:

Background

In highly parallel next-generation sequencing (NGS) techniques millions to billions of short reads are produced from a genomic sequence in a single run. Due to the limitation of the NGS technologies, there could be errors in the reads. The error rate of the reads can be reduced with trimming and by correcting the erroneous bases of the reads. It helps to achieve high quality data and the computational complexity of many biological applications will be greatly reduced if the reads are first corrected. We have developed a novel error correction algorithm called EC and compared it with four other state-of-the-art algorithms using both real and simulated sequencing reads.

Results

We have done extensive and rigorous experiments that reveal that EC is indeed an effectiv

SUBMITTER: Saha S 

PROVIDER: S-EPMC4674864 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature