Calcium and SOL Protease Mediate Temperature Resetting of Circadian Clocks.

ABSTRACT: Circadian clocks integrate light and temperature input to remain synchronized with the day/night cycle. Although light input to the clock is well studied, the molecular mechanisms by which circadian clocks respond to temperature remain poorly understood. We found that temperature phase shifts Drosophila circadian clocks through degradation of the pacemaker protein TIM. This degradation is mechanistically distinct from photic CRY-dependent TIM degradation. Thermal TIM degradation is triggered by cytosolic calcium increase and CALMODULIN binding to TIM and is mediated by the atypical calpain protease SOL. This thermal input pathway and CRY-dependent light input thus converge on TIM, providing a molecular mechanism for the integration of circadian light and temperature inputs. Mammals use bod

SUBMITTER: Tataroglu O 

PROVIDER: S-EPMC4675327 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature