Genomic Characterization of Upper Tract Urothelial Carcinoma.

ABSTRACT:

Background

Despite a similar histologic appearance, upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB) tumors have distinct epidemiologic and clinicopathologic differences.

Objective

To investigate whether the differences between UTUC and UCB result from intrinsic biological diversity.

Design, setting, and participants

Tumor and germline DNA from patients with UTUC (n=83) and UCB (n=102) were analyzed using a custom next-generation sequencing assay to identify somatic mutations and copy number alterations in 300 cancer-associated genes.

Outcome measurements and statistical analysis

We described co-mutation patterns and copy number alterations in UTUC. We also compared mutation frequencies in high-grade UTUC (n=59) and high-gra

SUBMITTER: Sfakianos JP 

PROVIDER: S-EPMC4675454 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature