Adverse Events Associated with Fosfomycin Use: Review of the Literature and Analyses of the FDA Adverse Event Reporting System Database.

ABSTRACT:

Introduction

The growing problem of antibacterial resistance resulted in an increased interest in fosfomycin, especially its parenteral formulation. We reviewed fosfomycin safety profile using the Food and Drug Administration Adverse Event (AE) Reporting System (FAERS) and published literature.

Methods

We conducted a FAERS search and disproportionality analysis of all fosfomycin-associated AEs. We also conducted a FAERS search for AEs implicating fosfomycin as the primary suspect and a search of reports of fosfomycin-associated bone marrow toxicity. We then review the literature for publications reporting AEs associated with fosfomycin by conducting PubMed searches.

Results

The disproportionality analysis of all FAERS reports of fosfomycin-associated AEs produced a hi

SUBMITTER: Iarikov D 

PROVIDER: S-EPMC4675770 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature