Evaluation of the relationship between effervescent paracetamol and blood pressure: clinical trial.

ABSTRACT:

Background

Paracetamol's solubility is achieved by adding to the excipient sodium salts, either as bicarbonate, carbonate or citrate. As the relationship between salt and hypertension is well known, due to the sodium content it has raised a hypothesis that may interfere with the control of that risk factor. Therefore, the objective of this study is to evaluate the effect on blood pressure of effervescent paracetamol compared to non-effervescent, in hypertensive patients.

Methods/design

This is the protocol of a phase IV multicenter clinical trial, randomized, controlled, crossover, open, which will compare the effect of two different formulations of paracetamol (effervescent or non-effervescent) in the blood pressure of hypertensive patients, with a seven weeks follow up. 49

SUBMITTER: Benitez-Camps M 

PROVIDER: S-EPMC4676099 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature