Sex differences in porcine left ventricular myocardial remodeling due to right ventricular pacing.

ABSTRACT:

Background

Although sex differences in heart failure (HF) prevalence and severity have been recognized, its molecular mechanisms are poorly understood. We used a tachycardia-induced cardiomyopathy model to determine the sex specific remodeling pattern in male and female adult pigs.

Methods

We compared the echocardiographic and molecular measures of myocardial remodeling in 19 male and 12 female pigs with chronic symptomatic systolic HF due to right ventricle (RV) pacing (170 bpm) and 6 male and 5 female sham-operated controls. Males achieved subsequent HF stages earlier than females.

Results

The progression of symptomatic HF was associated with the reduction of the left ventricle (LV) ejection fraction in both sexes (all p < 0.05). A significant LV dilatation occurred

SUBMITTER: Kiczak L 

PROVIDER: S-EPMC4676102 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature