Genome-Wide Scan for Adaptive Divergence and Association with Population-Specific Covariates.

ABSTRACT: In population genomics studies, accounting for the neutral covariance structure across population allele frequencies is critical to improve the robustness of genome-wide scan approaches. Elaborating on the BayEnv model, this study investigates several modeling extensions (i) to improve the estimation accuracy of the population covariance matrix and all the related measures, (ii) to identify significantly overly differentiated SNPs based on a calibration procedure of the XtX statistics, and (iii) to consider alternative covariate models for analyses of association with population-specific covariables. In particular, the auxiliary variable model allows one to deal with multiple testing issues and, providing the relative marker positions are available, to capture some linkage disequilibrium i

SUBMITTER: Gautier M 

PROVIDER: S-EPMC4676524 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature