Antigenic Maps of Influenza A(H3N2) Produced With Human Antisera Obtained After Primary Infection.

ABSTRACT:

Background

Antigenic characterization of influenza viruses is typically based on hemagglutination inhibition (HI) assay data for viral isolates tested against strain-specific postinfection ferret antisera. Here, similar virus characterizations were performed using serological data from humans with primary influenza A(H3N2) infection.

Methods

We screened sera collected between 1995 and 2011 from children between 9 and 24 months of age for influenza virus antibodies, performed HI tests for the positive sera against 23 influenza viruses isolated between 1989 and 2011, and measured HI titers of antisera against influenza A(H3N2) from 24 ferrets against the same panel of viruses.

Results

Of the 17 positive human sera, 6 had a high response, showing HI patterns that would b

SUBMITTER: Fonville JM 

PROVIDER: S-EPMC4676547 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature