Palmitoylethanolamide in Fibromyalgia: Results from Prospective and Retrospective Observational Studies.

ABSTRACT: INTRODUCTION:Fibromyalgia syndrome (FM) is characterized by persistent pain which is often refractory to common analgesic therapies and is particularly disabling. The objective of this study was to evaluate the therapeutic efficacy of duloxetine (DLX) + pregabalin (PGB) in patients suffering from FM and the possible added benefit of the lipid signaling molecule, palmitoylethanolamide (PEA). PEA is well-documented to exert anti-inflammatory, analgesic, and pain-relieving effects at both the preclinical and clinical level. METHODS:A total of 80 patients were recruited in two steps. The first was a retrospective observational study comprising 45 patients. This patient group received DLX + PGB for 6 months. The second step was a prospective observational study with 35 patients. Patients in thi

SUBMITTER: Del Giorno R 

PROVIDER: S-EPMC4676767 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature