Clostridium thermocellum DSM 1313 transcriptional responses to redox perturbation.

ABSTRACT:

Background

Clostridium thermocellum is a promising consolidated bioprocessing candidate organism capable of directly converting lignocellulosic biomass to ethanol. Current ethanol yields, productivities, and growth inhibitions are industrial deployment impediments for commodity fuel production by this bacterium. Redox imbalance under certain conditions and in engineered strains may contribute to incomplete substrate utilization and may direct fermentation products to undesirable overflow metabolites. Towards a better understanding of redox metabolism in C. thermocellum, we established continuous growth conditions and analyzed global gene expression during addition of two stress chemicals (methyl viologen and hydrogen peroxide) which changed the fermentation redox potential.

Resu

SUBMITTER: Sander K 

PROVIDER: S-EPMC4676874 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature