Bolus Estimation--Rethinking the Effect of Meal Fat Content.

ABSTRACT:

Background

Traditionally, insulin bolus calculations for managing postprandial glucose levels in individuals with type 1 diabetes rely solely on the carbohydrate content of a meal. However, recent studies have reported that other macronutrients in a meal can alter the insulin required for good postprandial control. Specifically, studies have shown that high-fat (HF) meals require more insulin than low-fat (LF) meals with identical carbohydrate content. Our objective was to assess the mechanisms underlying the higher insulin requirement observed in one of these studies.

Materials and methods

We used a combination of previously validated metabolic models to fit data from a study comparing HF and LF dinners with identical carbohydrate content in seven subjects with type 1 diabe

SUBMITTER: Laxminarayan S 

PROVIDER: S-EPMC4677112 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature