Genetic Moderation of Stress Effects on Corticolimbic Circuitry.

ABSTRACT: Stress exposure is associated with individual differences in corticolimbic structure and function that often mirror patterns observed in psychopathology. Gene x environment interaction research suggests that genetic variation moderates the impact of stress on risk for psychopathology. On the basis of these findings, imaging genetics, which attempts to link variability in DNA sequence and structure to neural phenotypes, has begun to incorporate measures of the environment. This research paradigm, known as imaging gene x environment interaction (iGxE), is beginning to contribute to our understanding of the neural mechanisms through which genetic variation and stress increase psychopathology risk. Although awaiting replication, evidence suggests that genetic variation within the canonical neu

SUBMITTER: Bogdan R 

PROVIDER: S-EPMC4677127 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature