Androgen Modulates Functions of Endothelial Progenitor Cells through Activated Egr1 Signaling.

ABSTRACT: Researches show that androgens have important effects on migration of endothelial cells and endothelial protection in coronary heart disease. Endothelial progenitor cells (EPCs) as a progenitor cell type that can differentiate into endothelial cells, have a critical role in angiogenesis and endothelial protection. The relationship between androgen and the functions of EPCs has animated much interest and controversy. In this study, we investigated the angiogenic and migratory functions of EPCs after treatment by dihydrotestosterone (DHT) and the molecular mechanisms as well. We found that DHT treatment enhanced the incorporation of EPCs into tubular structures formed by HUVECs and the migratory activity of EPCs in the transwell assay dose dependently. Moreover, microarray analysis was perfo

SUBMITTER: Ye Y 

PROVIDER: S-EPMC4677258 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature