Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy.

ABSTRACT:

Background

Medulloblastomas in children can be categorized into 4 molecular subgroups with differing clinical characteristics, such that subgroup determination aids in prognostication and risk-adaptive treatment strategies. Magnetic resonance spectroscopy (MRS) is a widely available, noninvasive tool that is used to determine the metabolic characteristics of tumors and provide diagnostic information without the need for tumor tissue. In this study, we investigated the hypothesis that metabolite concentrations measured by MRS would differ between molecular subgroups of medulloblastoma and allow accurate subgroup determination.

Methods

MRS was used to measure metabolites in medulloblastomas across molecular subgroups (SHH = 12, Groups 3/4 = 17, WNT = 1). Levels of 14 metabolit

SUBMITTER: Bluml S 

PROVIDER: S-EPMC4677409 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature