Noninvasive Reactivation of Motor Descending Control after Paralysis.

ABSTRACT: The present prognosis for the recovery of voluntary control of movement in patients diagnosed as motor complete is generally poor. Herein we introduce a novel and noninvasive stimulation strategy of painless transcutaneous electrical enabling motor control and a pharmacological enabling motor control strategy to neuromodulate the physiological state of the spinal cord. This neuromodulation enabled the spinal locomotor networks of individuals with motor complete paralysis for 2-6 years American Spinal Cord Injury Association Impairment Scale (AIS) to be re-engaged and trained. We showed that locomotor-like stepping could be induced without voluntary effort within a single test session using electrical stimulation and training. We also observed significant facilitation of voluntary influence

SUBMITTER: Gerasimenko YP 

PROVIDER: S-EPMC4677519 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature