Current Smoking Status Is Associated With Lower Quantitative CT Measures of Emphysema and Gas Trapping.

ABSTRACT:

Purpose

The purposes of this study were to evaluate the effect of smoking status on quantitative computed tomography CT measures of low-attenuation areas (LAAs) on inspiratory and expiratory CT and to provide a method of adjusting for this effect.

Materials and methods

A total of 6762 current and former smokers underwent spirometry and volumetric inspiratory and expiratory CT. Quantitative CT analysis was completed using open-source 3D Slicer software. LAAs were defined as lung voxels with attenuation values ≤-950 Hounsfield units (HU) on inspiratory CT and ≤-856 HU on expiratory CT and were expressed as percentage of CT lung volume (%LAAI-950 and %LAAE-856). Multiple linear regression was used to determine the effect of smoking status on %LAAI-950 and %LAAE-856 while contro

SUBMITTER: Zach JA 

PROVIDER: S-EPMC4677600 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature