Spherical nanoparticle supported lipid bilayers for the structural study of membrane geometry-sensitive molecules.

ABSTRACT: Many essential cellular processes including endocytosis and vesicle trafficking require alteration of membrane geometry. These changes are usually mediated by proteins that can sense and/or induce membrane curvature. Using spherical nanoparticle supported lipid bilayers (SSLBs), we characterize how SpoVM, a bacterial development factor, interacts with differently curved membranes by magic angle spinning solid-state NMR. Our results demonstrate that SSLBs are an effective system for structural and topological studies of membrane geometry-sensitive molecules.

SUBMITTER: Fu R 

PROVIDER: S-EPMC4677685 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature