Discovery of a Novel HDAC2 Inhibitor by a Scaffold-Merging Hybrid Query.

ABSTRACT: Histone deacetylases (HDACs) are part of a vast family of enzymes with crucial roles in numerous biological processes, largely through their repressive influence on transcription, with serious implications in a variety of human diseases. Among different isoforms, human HDAC2 in particular draws attention as a promising target for the treatment of cancer and memory deficits associated with neurodegenerative diseases. Now the challenge is to obtain a compound that is structurally novel and truly selective to HDAC2 because most current HDAC2 inhibitors do not show isoforms selectivity and suffer from metabolic instability. In order to identify novel, and isoform-selective inhibitors for human HDAC2, we designed a shape-based hybrid query from multiple scaffolds of known chemical classes and v

SUBMITTER: Basant N 

PROVIDER: S-EPMC4677828 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature