Urinary phthalate metabolites and ovarian reserve among women seeking infertility care.

ABSTRACT:

Study question

Are urinary phthalate metabolites associated with reduced antral follicle growth among women in an infertility setting?

Summary answer

Higher urinary concentrations of di(2-ethylhexyl) phthalate (DEHP) metabolites were associated with significant decreases in antral follicle count (AFC) among women seeking infertility care.

What is known already

Experimental animal studies show that DEHP accelerates primordial follicle recruitment and inhibits antral follicle growth. Whether phthalates also reduce the growing antral follicle pool in humans remains unknown.

Study design, size, duration

We examined the association between urinary phthalate metabolites and AFC using prospective data from 215 females recruited between 2004 and 2012 in the Environment

SUBMITTER: Messerlian C 

PROVIDER: S-EPMC4677966 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature