Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.

ABSTRACT:

Background

Epidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood. We investigated whether this phenotypic association arises from a shared genetic basis.

Methods and results

Using summary statistics (P values and odds ratios) from genome-wide association studies of >200 000 individuals, we investigated overlap in single-nucleotide polymorphisms associated with clinically diagnosed AD and C-reactive protein (CRP), triglycerides, and high- and low-density lipoprotein levels. We found up to 50-fold enrichment of AD single-nucleotide polymorphisms for different levels of association with C-reactive protein, low-density lipoprotein, high-density lipoprotein, a

SUBMITTER: Desikan RS 

PROVIDER: S-EPMC4677995 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature