Misoprostol for Labour Induction after Previous Caesarean Section - Forever a "No Go"?

ABSTRACT: Misoprostol in oral or vaginal form is an established method of labour induction worldwide. Its use after previous caesarean section is associated with a high rate of uterine rupture; according to international guidelines it is therefore contraindicated in this setting. However the evidence base for this recommendation comprises case reports, one randomised trial that was discontinued prematurely, and numerous low quality retrospective data analyses published between 1997 and 2004. New insights into e.g. resorption kinetics, dosage and application intervals, dose dependant uterine hyperstimulation rates, as well as increasing clinical experience with misoprostol have lead to a critical reappraisal of these "historical" studies. Accordingly the evidence supporting a ban on vaginal and parti

SUBMITTER: Rath W 

PROVIDER: S-EPMC4678051 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature