Genomic Epidemiology of USA300 Methicillin-Resistant Staphylococcus aureus in an Urban Community.

ABSTRACT:

Background

In a community, it is unknown what factors account for transmission of methicillin-resistant Staphylococcus aureus (MRSA). We integrated whole genome sequencing (WGS) and epidemiologic data to identify factors associated with MRSA transmission networks in an urban community.

Methods

WGS was performed on colonizing USA300 MRSA isolates from 74 individuals within 72 hours of admission to a public hospital in Chicago, IL. Single nucleotide variants (SNVs) were used to reconstruct the phylogeny of sequenced isolates, and epidemiologic data was overlaid to identify factors associated with transmission networks.

Results

The maximum within-patient SNV difference for an individual with multisite colonization was 41 SNVs, with no systematic divergence among body sit

SUBMITTER: Popovich KJ 

PROVIDER: S-EPMC4678108 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature