Intestinal Microbiota Signatures Associated with Inflammation History in Mice Experiencing Recurring Colitis.

ABSTRACT: Acute colitis causes alterations in the intestinal microbiota, but the microbiota is thought to recover after such events. Extreme microbiota alterations are characteristic of human chronic inflammatory bowel diseases, although alterations reported in different studies are divergent and sometimes even contradictory. To better understand the impact of periodic disturbances on the intestinal microbiota and its compositional difference between acute and relapsing colitis, we investigated the beginnings of recurrent inflammation using the dextran sodium sulfate (DSS) mouse model of chemically induced colitis. Using bacterial 16S rRNA gene-targeted pyrosequencing as well as quantitative fluorescence in situ hybridization, we profiled the intestinal and stool microbiota of mice over the course o

SUBMITTER: Berry D 

PROVIDER: S-EPMC4678223 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature