Changes in the Golgi Apparatus of Neocortical and Hippocampal Neurons in the Hibernating Hamster.

ABSTRACT: Hibernating animals have been used as models to study several aspects of the plastic changes that occur in the metabolism and physiology of neurons. These models are also of interest in the study of Alzheimer's disease because the microtubule-associated protein tau is hyperphosphorylated during the hibernation state known as torpor, similar to the pretangle stage of Alzheimer's disease. Hibernating animals undergo torpor periods with drops in body temperature and metabolic rate, and a virtual cessation of neural activity. These processes are accompanied by morphological and neurochemical changes in neurons, which reverse a few hours after coming out of the torpor state. Since tau has been implicated in the structural regulation of the neuronal Golgi apparatus (GA) we have used Western Blot

SUBMITTER: Anton-Fernandez A 

PROVIDER: S-EPMC4678224 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature