Modeling early haematologic adverse events in conformal and intensity-modulated pelvic radiotherapy in anal cancer.

ABSTRACT:

Background and purpose

To determine if there are differences between dose to pelvic bone marrow (PBM) using intensity modulated radiotherapy (IMRT) under UK guidance versus conformal radiotherapy (CRT) per ACT II protocol and if differences translate to rates of early haematological adverse events grade 3 or greater (HT3+).

Methods and materials

Two groups of 20+ patients, treated under IMRT and CRT regimes respectively, were identified. All patients underwent weekly blood cell count: haemoglobin (HgB), white cell count (WCC), absolute neutrophil count (ANC) and platelets (plats). Percent volume of PBM and sub structures receiving 5-25 Gy were tested for statistical significance. Regression models were used to test for correlation to blood counts. NTCP modeling was also perf

SUBMITTER: Robinson M 

PROVIDER: S-EPMC4678285 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature