Regional Neocortical Gray Matter Structure and Sleep Fragmentation in Older Adults.

ABSTRACT:

Study objectives

To test the hypothesis that greater sleep fragmentation is associated with regionally decreased cortical gray matter volume in older community-dwelling adults without cognitive impairment.

Methods

We studied 141 community-dwelling older adults (median age 82.9; 73% female) without cognitive impairment or stroke, and not using sedative/ hypnotic medications, participating in the Rush Memory and Aging Project. We quantified sleep fragmentation from 7 d of actigraphy using the metric kRA and related this to total cortical gray matter volume, and regional gray matter volume in 34 cortical regions quantified by automated segmentation of magnetic resonance imaging data. We determined statistical significance and accounted for multiple comparisons by empirically es

SUBMITTER: Lim AS 

PROVIDER: S-EPMC4678338 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature