Direct catalytic enantio- and diastereoselective ketone aldol reactions of isocyanoacetates.

ABSTRACT: A catalytic asymmetric aldol addition/cyclization reaction of unactivated ketones with isocyanoacetate pronucleophiles has been developed. A quinine-derived aminophosphine precatalyst and silver oxide were found to be an effective binary catalyst system and promoted the reaction to afford chiral oxazolines possessing a fully substituted stereocenter with good diastereoselectivities and excellent enantioselectivities.

SUBMITTER: de la Campa R 

PROVIDER: S-EPMC4678506 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature