MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells.

ABSTRACT: MicroRNAs (miRNAs) are a class of small, non-coding RNAs that posttranscriptionally regulate gene expression and thereby control most, if not all, biological processes. Aberrant miRNA expression has been linked to a variety of human diseases including cancer, but the underlying molecular mechanism often remains unclear. Here we have screened a miRNA expression library in a growth factor-dependent mouse pre-B-cell system to identify miRNAs with oncogenic activity. We show that miR-125b is sufficient to render pre-B cells growth factor independent and demonstrate that continuous expression of miR-125b is necessary to keep these cells in a transformed state. Mechanistically, we find that the expression of miR-125b protects against apoptosis induced by growth factor withdrawal, and that it blo

SUBMITTER: Knackmuss U 

PROVIDER: S-EPMC4678593 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature