Ontology highlight
ABSTRACT:
SUBMITTER: Rydzik AM
PROVIDER: S-EPMC4678601 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Rydzik Anna M AM Chowdhury Rasheduzzaman R Kochan Grazyna T GT Williams Sophie T ST McDonough Michael A MA Kawamura Akane A Schofield Christopher J CJ
Chemical science 20140501 5
Carnitine is essential for fatty acid metabolism, but is associated with both health benefits and risks, especially heart diseases. We report the identification of potent, selective and cell active inhibitors of γ-butyrobetaine hydroxylase (BBOX), which catalyses the final step of carnitine biosynthesis in animals. A crystal structure of BBOX in complex with a lead inhibitor reveals that it binds in two modes, one of which adopts an unusual 'U-shape' conformation stabilised by inter- and intra-m ...[more]