The administration of intranasal live attenuated influenza vaccine induces changes in the nasal microbiota and nasal epithelium gene expression profiles.

ABSTRACT:

Background

Viral infections such as influenza have been shown to predispose hosts to increased colonization of the respiratory tract by pathogenic bacteria and secondary bacterial pneumonia. To examine how viral infections and host antiviral immune responses alter the upper respiratory microbiota, we analyzed nasal bacterial composition by 16S ribosomal RNA (rRNA) gene sequencing in healthy adults at baseline and at 1 to 2 weeks and 4 to 6 weeks following instillation of live attenuated influenza vaccine or intranasal sterile saline. A subset of these samples was submitted for microarray host gene expression profiling.

Results

We found that live attenuated influenza vaccination led to significant changes in microbial community structure, diversity, and core taxonomic members

SUBMITTER: Tarabichi Y 

PROVIDER: S-EPMC4678663 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature