Collagen Promotes Higher Adhesion, Survival and Proliferation of Mesenchymal Stem Cells.

ABSTRACT: Mesenchymal stem cells (MSC) can differentiate into several cell types and are desirable candidates for cell therapy and tissue engineering. However, due to poor cell survival, proliferation and differentiation in the patient, the therapy outcomes have not been satisfactory. Although several studies have been done to understand the conditions that promote proliferation, differentiation and migration of MSC in vitro and in vivo, still there is no clear understanding on the effect of non-cellular bio molecules. Of the many factors that influence the cell behavior, the immediate cell microenvironment plays a major role. In this context, we studied the effect of extracellular matrix (ECM) proteins in controlling cell survival, proliferation, migration and directed MSC differentiation. We found

SUBMITTER: Somaiah C 

PROVIDER: S-EPMC4678765 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature