Evolution of practice during the Interventional Management of Stroke III Trial and implications for ongoing trials.

ABSTRACT:

Background and purpose

We explored changes in the patient population and practice of endovascular therapy during the course of the Interventional Management of Stroke (IMS) III Trial.

Methods

Changes in baseline characteristics, use of baseline CT angiography, treatment times and specifics, and outcomes were compared between the first 4 protocols and the fifth and final protocol.

Results

Compared with subjects treated in the first 4 protocol versions (n=610), subjects treated in fifth and final protocol (n=46) were older (75 versus 68 years, P<0.0002) and less likely to have a pretreatment Rankin of 0 (76% versus 89%, P=0.01), were more likely to have a pretreatment CT angiography (65% versus 45%, P=0.009), had quicker median times in the endovascular arm from onset t

SUBMITTER: Broderick JP 

PROVIDER: S-EPMC4679363 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature