Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model.

ABSTRACT:

Rationale

Tissue engineering approaches may improve survival and functional benefits from human embryonic stem cell-derived cardiomyocyte transplantation, thereby potentially preventing dilative remodeling and progression to heart failure.

Objective

Assessment of transport stability, long-term survival, structural organization, functional benefits, and teratoma risk of engineered heart muscle (EHM) in a chronic myocardial infarction model.

Methods and results

We constructed EHMs from human embryonic stem cell-derived cardiomyocytes and released them for transatlantic shipping following predefined quality control criteria. Two days of shipment did not lead to adverse effects on cell viability or contractile performance of EHMs (n=3, P=0.83, P=0.87). One month after isc

SUBMITTER: Riegler J 

PROVIDER: S-EPMC4679370 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature