Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH.

ABSTRACT: Absorption of 808 nm laser light by liposomes containing a pH sensitive, near-infrared croconaine rotaxane dye increases dramatically in weak acid. A stealth liposome composition permits acid activated, photothermal heating and also acts as an effective nanoparticle probe for ratiometric photoacoustic imaging of acidic pH in deep sample locations, including a living mouse.

SUBMITTER: Guha S 

PROVIDER: S-EPMC4679412 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature