Uterine overdistention induces preterm labor mediated by inflammation: observations in pregnant women and nonhuman primates.

ABSTRACT:

Objective

Uterine overdistention is thought to induce preterm labor in women with twin and multiple pregnancies, but the pathophysiology remains unclear. We investigated for the first time the pathogenesis of preterm birth associated with rapid uterine distention in a pregnant nonhuman primate model.

Study design

A nonhuman primate model of uterine overdistention was created using preterm chronically catheterized pregnant pigtail macaques (Macaca nemestrina) by inflation of intraamniotic balloons (N = 6), which were compared to saline controls (N = 5). Cesarean delivery was performed due to preterm labor or at experimental end. Microarray, quantitative reverse transcriptase polymerase chain reaction, Luminex (Austin, TX), and enzyme-linked immunosorbent assay were used to me

SUBMITTER: Adams Waldorf KM 

PROVIDER: S-EPMC4679421 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature