Suboptimal cytoreduction in ovarian carcinoma is associated with molecular pathways characteristic of increased stromal activation.

ABSTRACT:

Objective

Suboptimal cytoreductive surgery in advanced epithelial ovarian cancer (EOC) is associated with poor survival but it is unknown if poor outcome is due to the intrinsic biology of unresectable tumors or insufficient surgical effort resulting in residual tumor-sustaining clones. Our objective was to identify the potential molecular pathway(s) and cell type(s) that may be responsible for suboptimal surgical resection.

Methods

By comparing gene expression in optimally and suboptimally cytoreduced patients, we identified a gene network associated with suboptimal cytoreduction and explored the biological processes and cell types associated with this gene network.

Results

We show that primary tumors from suboptimally cytoreduced patients express molecular signature

SUBMITTER: Liu Z 

PROVIDER: S-EPMC4679504 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature