Asymmetric synthesis of 1H-pyrrol-3(2H)-ones from 2,3-diketoesters by combination of aldol condensation with benzilic acid rearrangement.

ABSTRACT: An efficient two-step protocol for the asymmetric synthesis of 1H-pyrrol-3(2H)-one derivatives in 99% ee from conveniently accessed 2,3-diketoesters has been developed.

SUBMITTER: Sha Q 

PROVIDER: S-EPMC4679521 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature