Energy homeostasis genes and breast cancer risk: The influence of ancestry, body size, and menopausal status, the breast cancer health disparities study.

ABSTRACT:

Background

Obesity and breast cancer risk is multifaceted and genes associated with energy homeostasis may modify this relationship.

Methods

We evaluated 10 genes that have been associated with obesity and energy homeostasis to determine their association with breast cancer risk in Hispanic/Native American (2111 cases, 2597 controls) and non-Hispanic white (1481 cases, 1585 controls) women.

Results

Cholecystokinin (CCK) rs747455 and proopiomelanocortin (POMC) rs6713532 and rs7565877 (for low Indigenous American (IA) ancestry); CCK rs8192472 and neuropeptide Y (NYP) rs16141 and rs14129 (intermediate IA ancestry); and leptin receptor (LEPR) rs11585329 (high IA ancestry) were strongly associated with multiple indicators of body size. There were no significant association

SUBMITTER: Slattery ML 

PROVIDER: S-EPMC4679560 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature