Mcm10 is required for oogenesis and early embryogenesis in Drosophila.

ABSTRACT: Efficient replication of the genome and the establishment of endogenous chromatin states are processes that are essential to eukaryotic life. It is well documented that Mcm10 is intimately linked to both of these important biological processes; therefore, it is not surprising that Mcm10 is commonly misregulated in many human cancers. Most of the research regarding the biological roles of Mcm10 has been performed in single-cell or cell-free in-vitro systems. Though these systems are informative, they are unable to provide information on the cell-specific function of Mcm10 in the context of the tissue and organ systems that comprise multicellular eukaryotes. We therefore sought to identify the potential biological functions of Mcm10 in the context of a complex multicellular organism by conti

SUBMITTER: Reubens MC 

PROVIDER: S-EPMC4679633 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature