New formulation of old aspirin for better delivery.

ABSTRACT: For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.

SUBMITTER: Kalathil AA 

PROVIDER: S-EPMC4679634 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature