Host Genetic Susceptibility to Enteric Viruses: A Systematic Review and Metaanalysis.

ABSTRACT:

Background

Norovirus and rotavirus are prominent enteric viruses responsible for severe acute gastroenteritis disease burden around the world. Both viruses recognize and bind to histo-blood group antigens, which are expressed by the fucosyltransferase 2 (FUT2) gene. Individuals with a functional FUT2 gene are termed "secretors." FUT2 polymorphisms may influence viral binding patterns and, therefore, may influence host susceptibility to infection by these viruses.

Methods

We performed a systematic review of the published literature on this topic. Data were abstracted and compiled for descriptive analyses and metaanalyses. We estimated pooled odds ratios (ORs) for infection using random-effects models.

Results

We found that secretors were 9.9 times (95% confidence inter

SUBMITTER: Kambhampati A 

PROVIDER: S-EPMC4679673 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature