Evolution of temporal and spectral dynamics of pathologic high-frequency oscillations (pHFOs) during epileptogenesis.

ABSTRACT:

Objective

In temporal lobe epilepsy (TLE), pathologic high frequency oscillations (pHFOs, 200-600 Hz) are present in the hippocampus, especially the dentate gyrus (DG). The pHFOs emerge during a latent period prior to the onset of spontaneous generalized seizures. We used a unilateral suprahippocampal injection of kainic acid (KA) mouse model of TLE to characterize the properties of hippocampal pHFOs during epileptogenesis.

Methods

In awake head-fixed mice, 4-14 days after KA-induced status epilepticus (SE), we recorded local field potentials (LFPs) with 64-channel silicon probes spanning from CA1 alveus to the DG hilus, or with glass pipettes in the DC mode in the CA1 str radiatum.

Results

The pHFOs, are observed simultaneously in the CA1 and the DG, or in the DG alo

SUBMITTER: Jones RT 

PROVIDER: S-EPMC4679703 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature