Quantitative Gene Expression by Recurrence Score in ER-Positive Breast Cancer, by Age.

ABSTRACT:

Introduction

Breast cancer in young women (<50 years) has been associated with an increased risk of recurrence and decreased survival compared with patients older than 50. The objective of this analysis was to determine, from a large database of patients with early-stage breast cancer, if the Recurrence Score(®) result (Oncotype DX(®), Genomic Health, Inc, Redwood City, CA, USA) provided clinically meaningful differences in predicted risk of recurrence in younger-compared with older-patients.

Methods

Tumor samples from patients with estrogen receptor (ER)-positive breast cancers that were successfully processed in the Genomic Health central lab between June 2004 and December 2013 for Recurrence Score and quantitative gene expression of ER, progesterone receptor (PR), and Her

SUBMITTER: Swain SM 

PROVIDER: S-EPMC4679789 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature