Exposure to welding fumes is associated with hypomethylation of the F2RL3 gene: a cardiovascular disease marker.

ABSTRACT:

Background

Welders are at risk for cardiovascular disease. Recent studies linked tobacco smoke exposure to hypomethylation of the F2RL3 (coagulation factor II (thrombin) receptor-like 3) gene, a marker for cardiovascular disease prognosis and mortality. However, whether welding fumes cause hypomethylation of F2RL3 remains unknown.

Methods

We investigated 101 welders (median span of working as a welder: 7 years) and 127 unexposed controls (non-welders with no obvious exposure to respirable dust at work), age range 23-60 years, all currently non-smoking, in Sweden. The participants were interviewed about their work history, lifestyle factors and diseases. Personal sampling of respirable dust was performed for the welders. DNA methylation of F2RL3 in blood was assessed by pyros

SUBMITTER: Hossain MB 

PROVIDER: S-EPMC4680149 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature