Factors influencing long-term outcomes in relapsing-remitting multiple sclerosis: PRISMS-15.

ABSTRACT:

Aim

An exploratory study of the relationship between cumulative exposure to subcutaneous (sc) interferon (IFN) β-1a treatment and other possible prognostic factors with long-term clinical outcomes in relapsing-remitting multiple sclerosis (RRMS).

Methods

Patients in the original PRISMS study were invited to a single follow-up visit 15 years after initial randomisation (PRISMS-15). Outcomes over 15 years were compared in the lowest and highest quartile of the cumulative sc IFN β-1a dose groups, and according to total time receiving sc IFN β-1a as a continuous variable per 5 years of treatment. Potential prognostic factors for outcomes were analysed.

Results

Of 560 patients randomised in PRISMS, 291 returned for PRISMS-15 and 290 (51.8%) were analysed. Higher cumulative

SUBMITTER: Kappos L 

PROVIDER: S-EPMC4680156 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature